CD32/CD16 Antikörper

Produktnummer ABIN1176962

Produktdetails anti-CD32/CD16 Antikörper

Target: CD32/CD16

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD32/CD16 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Blocking Reagent (BR)

Marke: BD Pharmingen™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogen: Mouse BALB/c Macrophage J774

Klon: 2-4G2

Isotyp: IgG2b kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-CD32/CD16 Antikörper (ABIN1176962)

Araujo-Jorge, Rivera, el Bouhdidi, Daëron, Carlier: "An Fc gamma RII-, Fc gamma RIII-specific monoclonal antibody (2.4G2) decreases acute Trypanosoma cruzi infection in mice." in: Infection and immunity, Vol. 61, Issue 11, pp. 4925-8, (1993) (PubMed).

Latour, Bonnerot, Fridman, Daëron: "Induction of tumor necrosis factor-alpha production by mast cells via Fc gamma R. Role of the Fc gamma RIII gamma subunit." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 6, pp. 2155-62, (1992) (PubMed).

Maeda, Burton, Padgett, Conrad, Huff, Masuda, Szakal, Tew: "Murine follicular dendritic cells and low affinity Fc receptors for IgE (Fc epsilon RII)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 8, pp. 2340-7, (1992) (PubMed).

Rodewald, Moingeon, Lucich, Dosiou, Lopez, Reinherz: "A population of early fetal thymocytes expressing Fc gamma RII/III contains precursors of T lymphocytes and natural killer cells." in: Cell, Vol. 69, Issue 1, pp. 139-50, (1992) (PubMed).

Ravetch, Luster, Weinshank, Kochan, Pavlovec, Portnoy, Hulmes, Pan, Unkeless: "Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors." in: Science (New York, N.Y.), Vol. 234, Issue 4777, pp. 718-25, (1986) (PubMed).

Titus, Finkelman, Stephany, Jones, Segal: "Quantitative analysis of Fc gamma receptors on murine spleen cell populations by using dual parameter flow cytometry." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 133, Issue 2, pp. 556-61, (1984) (PubMed).

Mellman, Unkeless: "Purificaton of a functional mouse Fc receptor through the use of a monoclonal antibody." in: The Journal of experimental medicine, Vol. 152, Issue 4, pp. 1048-69, (1980) (PubMed).

Unkeless: "Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors." in: The Journal of experimental medicine, Vol. 150, Issue 3, pp. 580-96, (1979) (PubMed).

Details zu CD32/CD16

Target: CD32/CD16

Andere Bezeichnung: CD16/CD32 (CD32/CD16 Produkte)

Hintergrund: The 2.4G2 antibody reacts specifically with a common nonpolymorphic epitope on the extracellular domains of the mouse FcgammaIII and FcgammaII receptors. It has also been reported to bind the FcgammaI receptor (CD64) via its Fc domain. 2.4G2 mAb blocks non-antigen-specific binding of immunoglobulins to the FcgammaIII and FcgammaII, and possibly FcgammaI, receptors in vitro and in vivo. CD16 and/or CD32 are expressed on natural killer cells, monocytes, macrophages, dendritic cells (at low levels), Kupffer cells, granulocytes, mast cells, B lymphocytes, immature thymocytes, and some activated mature T lymphocytes.
Synonyms: FcgammaRIII/FcgammaRII, Fcgr3/Fcgr2