CD20 Antikörper (Cytoplasmic) (APC-H7)

Produktnummer ABIN1176878

Der Maus Monoklonal Anti-CD20-Antikörper wurde für ICS validiert. Er ist geeignet, CD20 in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für CD20 Antikörper (Cytoplasmic) (APC-H7) (ABIN1176878)

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD20 Antikörper ist konjugiert mit APC-H7

Applikation: Intracellular Staining (ICS)

Klon: H1

Produktdetails anti-CD20 Antikörper (APC-H7)

Bindungsspezifität: Cytoplasmic

Marke: BD Phosflow™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human B lymphoma cell line

Isotyp: IgG2a kappa

Anwendungsinformationen

Kommentare:

BALB/c

Probenmenge: 5 μL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with APC-H7 under optimum conditions, and unconjugated antibody and APC-H7 were removed.

Referenzen für anti-CD20 Antikörper (APC-H7) (ABIN1176878)

Cragg, Walshe, Ivanov, Glennie: "The biology of CD20 and its potential as a target for mAb therapy." in: Current directions in autoimmunity, Vol. 8, pp. 140-74, (2004) (PubMed).

Details zu CD20

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Andere Bezeichnung: CD20

Hintergrund: The H1 (FB1) antibody specificially binds to a cytoplasmic domain of CD20. CD20 is a 33-37-kDa four transmembrane phosphoprotein that is expressed by B lymphocytes from the pre-B stage and most malignant B cells and is lost during plasma cell differentiation. Low level CD20 expression is observed on a subset of normal circulating T lymphocytes, and CD20-positive T-cell lymphomas have been reported. The CD20 molecule is associated with membrane lipid raft domains, acts as a channel for calcium ions, and is involved in the regulation of B cell activation and survival. The cytoplasmic domain regions are serine and threonine rich and contain multiple phosphorylation consensus sequences.
Synonyms: MS4A1, membrane-spanning 4-domains subfamily A member 1, B1, Bp35, LEU-16