CD3 MOLCPX Antikörper
Reaktivität: Maus
FACS
Wirt: Ratte
Monoclonal
17A2
unconjugated
(2 Referenzen)-
- Target
- CD3 MOLCPX
- Reaktivität
- Maus
- Wirt
- Ratte
- Klonalität
- Monoklonal
- Applikation
- Flow Cytometry (FACS)
- Marke
- BD Pharmingen™
- Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Sterilität
- 0.2 μm filtered
- Endotoxin-Niveau
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- Immunogen
- gammadelta TCR-positive T-T hybridoma D1
- Klon
- 17A2
- Isotyp
- IgG2b kappa
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.0 mg/mL
- Buffer
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- Konservierungsmittel
- Azide free
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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: "Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in ..." in: Blood, Vol. 80, Issue 10, pp. 2661-7, (1992) (PubMed).
: "Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex." in: Immunology letters, Vol. 23, Issue 2, pp. 113-8, (1990) (PubMed).
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: "Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in ..." in: Blood, Vol. 80, Issue 10, pp. 2661-7, (1992) (PubMed).
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- Target
- CD3 MOLCPX
- Hintergrund
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The 17A2 monoclonal antibody specifically binds to the T-cell receptor-associated CD3 complex that is expressed on many thymocytes and mature T lymphocytes. Plate-bound 17A2 antibody has been reported to induce IL-2 production by cultured T cells in the absence of accessory cells. The binding of the 17A2 antibody to T cells can be blocked by the anti-CD3e mAb 145-2C11. This suggests that the 17A2 antibody recognizes an epitope of the CD3 epsilon chain. In vivo treatment with 17A2 antibody has been reported to partially deplete T lymphocytes and temporarily down-modulates CD3 expression on T cells.
Synonyms: CD3, CD3 epsilon, Cd3e, CD3epsilon, T3e
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