Granulin Antikörper

Produktnummer ABIN1169392

Dieser Ratte Polyklonal Antikörper detektiert spezifisch Granulin in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für Granulin Antikörper (ABIN1169392)

Target: Granulin (GRN)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Polyklonal

Konjugat: Dieser Granulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Granulin Antikörper

Verwendungszweck: anti-Progranulin (mouse), pAb

Spezifität: Recognizes mouse progranulin. Detects a band of ~90 kDa by Western blot. Weakly cross-reacts with human progranulin.

Kreuzreaktivität (Details): Weakly cross-reacts with human progranulin.

Produktmerkmale: Polyclonal Antibody. Recognizes mouse progranulin. Detects a band of ~90 kDa by Western blot. Weakly cross-reacts with human progranulin. Source: Rat. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Sterilität: 0.2 μm filtered

Immunogen: Recombinant mouse progranulin.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Konservierungsmittel: Without preservative

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Details zu Granulin

Target: Granulin (GRN)

Andere Bezeichnung: Progranulin

Hintergrund:

Alternate Names/Synonyms: Proepithelin, PEPI, PC Cell-derived Growth Factor

Product Description: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

UniProt: P28798