Caspase 1 p20 Antikörper (Biotin)

Produktnummer ABIN1169383

Dieser Maus Monoklonal Antikörper detektiert spezifisch Caspase 1 p20 in WB, IP und IHC. Es zeigt Reaktivität gegenüber Proben von Maus.Es wurde in 1 Publikation zitiert.

Kurzübersicht für Caspase 1 p20 Antikörper (Biotin) (ABIN1169383)

Target: Caspase 1 p20

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Caspase 1 p20 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Klon: Casper-1

Produktdetails anti-Caspase 1 p20 Antikörper (Biotin)

Verwendungszweck: anti-Caspase-1 (p20) (mouse), mAb (Casper-1) (Biotin)

Spezifität: Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.

Produktmerkmale: Monoclonal Antibody. Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1. Isotype: Mouse IgG1. Clone: Casper-1. Applications: IHC, IP, WB. Liquid. In PBS containing 0.02 % sodium azide. Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant mouse caspase-1.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: In PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-Caspase 1 p20 Antikörper (Biotin) (ABIN1169383)

Carpentier, Ni, Duggan, James, Cookson, Hamerman: "The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1." in: Science signaling, Vol. 12, Issue 581, (2020) (PubMed).

Details zu Caspase 1 p20

Target: Caspase 1 p20

Andere Bezeichnung: Caspase-1 p20

Hintergrund:

Alternate Names/Synonyms: Interleukin-1beta Convertase, IL-1BC, Interleukin-1beta-converting Enzyme, ICE,

Product Description: Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

UniProt: P29452