ZBP1 Antikörper (AA 1-411)

Produktnummer ABIN1169142

Dieses Anti-ZBP1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ZBP1 in WB, IP und ICC. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für ZBP1 Antikörper (AA 1-411) (ABIN1169142)

Target: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ZBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Klon: Zippy-1

Produktdetails anti-ZBP1 Antikörper

Bindungsspezifität: AA 1-411

Spezifität: Recognizes human and mouse ZBP1.

Kreuzreaktivität: Human, Maus

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant mouse ZBP1 (aa 1-411)

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-ZBP1 Antikörper (ABIN1169142)

Christgen, Zheng, Kesavardhana, Karki, Malireddi, Banoth, Place, Briard, Sharma, Tuladhar, Samir, Burton, Kanneganti: "Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)." in: Frontiers in cellular and infection microbiology, Vol. 10, pp. 237, (2020) (PubMed).

Kuriakose, Zheng, Neale, Kanneganti: "IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 4, pp. 1489-1495, (2019) (PubMed).

Kesavardhana, Kuriakose, Guy, Samir, Malireddi, Mishra, Kanneganti: "ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death." in: The Journal of experimental medicine, Vol. 214, Issue 8, pp. 2217-2229, (2017) (PubMed).

Details zu ZBP1

Target: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Andere Bezeichnung: ZBP1

Hintergrund: ZBP1 is an interferon inducible protein that binds to cytoplasmic DNA and plays a role in host defense against tumors and pathogens. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. ZBP1 is an innate immune sensor of Influenza A virus (IAV). ZBP1 regulates NLRP3 (nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin domain containing 3) inflammasome activation as well as induction of different types of cell death (apoptosis, necroptosis and pyroptosis) during IAV infection.

UniProt: Q9H171