Periostin Antikörper (full length)

Produktnummer ABIN1169103

Produktdetails anti-Periostin Antikörper

Target: Periostin (POSTN)

Bindungsspezifität: full length

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Periostin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: Recognizes human and mouse periostin.

Kreuzreaktivität: Human, Maus

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Full-length human periostin.

Klon: Stiny-1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-Periostin Antikörper (ABIN1169103)

Wang, Liu, Wang, Huang, Liu, Zhu, Cai, Fang, Lin, Yuan, Ouyang: "Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells." in: PLoS ONE, Vol. 8, Issue 8, pp. e72962, (2013) (PubMed).

Ghajar, Peinado, Mori, Matei, Evason, Brazier, Almeida, Koller, Hajjar, Stainier, Chen, Lyden, Bissell: "The perivascular niche regulates breast tumour dormancy." in: Nature cell biology, Vol. 15, Issue 7, pp. 807-17, (2013) (PubMed).

Details zu Periostin

Target: Periostin (POSTN)

Andere Bezeichnung: Periostin (POSTN Produkte)

Hintergrund: Periostin is a 90- kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.

UniProt: Q15063