TRIB3 Antikörper (AA 112-125)

Produktnummer ABIN1169021

Der Kaninchen Polyklonal anti-TRIB3 Antikörper wird verwendet zum Nachweis von TRIB3 in Proben von Human. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für TRIB3 Antikörper (AA 112-125) (ABIN1169021)

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TRIB3 Antikörper

Bindungsspezifität: AA 112-125

Verwendungszweck: anti-TRB-3 (human), pAb

Spezifität: Recognizes human TRB-3. Detects a band of ~28 kDa by Western blot (predicted 39 kDa).

Produktmerkmale: Polyclonal Antibody. Recognizes human TRB-3. Detects a band of ~28 kDa by Western blot (predicted 39 kDa). Source: Rabbit. Applications: ELISA, IHC, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Tribbles homolog 3 (TRB-3) is a pseudokinase, shown to act as a potent negative regulator of PPARgamma, a master regulator of adipocyte differentiation, and to control adipogenesis. It disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. It interacts also with the NF-kappaB transactivator p65 RELA. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells.

Sterilität: 0.2 μm filtered

Immunogen: Synthetic peptide corresponding to aa 112-125 (A112RLPPHKHVARPTE125) of human TRB-3.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Konservierungsmittel: Without preservative

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Details zu TRIB3

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Andere Bezeichnung: TRB-3

Hintergrund:

Alternate Names/Synonyms: Tribbles Homolog 3, Neuronal Cell death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappaB

Product Description: Tribbles homolog 3 (TRB-3) is a pseudokinase, shown to act as a potent negative regulator of PPARgamma, a master regulator of adipocyte differentiation, and to control adipogenesis. It disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. It interacts also with the NF-kappaB transactivator p65 RELA. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells.

UniProt: Q96RU7

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Lipid Metabolism by PPARalpha