Cytokeratin 1 Antikörper (pan)

Produktnummer ABIN115296

Der Kaninchen Polyklonal anti-Cytokeratin 1 Antikörper (ABIN115296) detektiert spezifisch Cytokeratin 1 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Cytokeratin 1 Antikörper (pan) (ABIN115296)

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cytokeratin 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Cytokeratin 1 Antikörper

Bindungsspezifität: pan

Spezifität: This antibody reacts with Cytokeratins of 68, 60, 58, 56, 52, 51, and 68 kDa MW. It is well suited for the staining of a broad spectrum of keratins. Cellular localization: cytoplasmic.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Purified

Immunogen: Cytokeratin isolated from bovine muzzle epidermis

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Formalin-Fixed Paraffin Embedded Tissues: This antibody maybe diluted to a titer of 1/75-1/200 in an ABC method (30 minutes at room temperature). Proteolytic enzymatic pretreatment of formalin fixed paraffin embedded sections isrecommended prior to immunostaining. Recommended Positive Control: skin.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu Cytokeratin 1

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Andere Bezeichnung: Cytokeratin

Hintergrund: Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 1, 4, 5, 6, and 8 are members of the type II neutral to basic subfamily. Monoclonal anti cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Monoclonal Anti Pan Cytokeratin (mixture) is a broadly reactive reagent, which recognizes epitopes present in most human epithelial tissues. It facilitates typing of normal, metaplastic and neoplastic cells. Synergy between the various components results in staining amplification. This enables identification of cells, which would otherwise be stained only marginally. The mixture may aid in the discrimination of carcinomas and nonepithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micrometastases in lymph nodes, bone marrow and other tissues and for determining the origin of poorly differentiated tumors. There are two types of cytokeratins the acidic type I cytokeratins and the basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Usually the type II cytokeratins are 8kD larger than their type I counterparts.Synonyms: Cytokeratin pan-reactive, pan Keratin