CRP Antikörper

Produktnummer ABIN114518

Der Maus Monoklonal anti-CRP Antikörper wird verwendet zum Nachweis von CRP in Proben von Human. Er wurde validiert für WB, EIA und ELISA (Capture).

Kurzübersicht für CRP Antikörper (ABIN114518)

Target: CRP (C-Reactive Protein (CRP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CRP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), ELISA (Capture)

Klon: 63F4

Produktdetails anti-CRP Antikörper

Spezifität: Recognizes Human CRP. No detectable cross-reaction with Human normal serum proteins. Other species not tested.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: Purified CRP from Human pleural fluid

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Immunoblot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with Double distillated water is recommended and to adjust the final concentration to 1.0 mg/mL

Konzentration: 1.0 mg/mL

Buffer: 0.01 M PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CRP

Target: CRP (C-Reactive Protein (CRP))

Hintergrund: C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.Synonyms: C Reactive Protein, PTX1, Pentraxin-related

Gen-ID: 1401

NCBI Accession: NP_000558

UniProt: P02741

Pathways: Carbohydrate Homeostasis