ITM2B Antikörper

Produktnummer ABIN113338

Dieses Huhn Polyklonal-Antikörper erkennt spezifisch ITM2B in IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ITM2B Antikörper (ABIN113338)

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Reaktivität: Human

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser ITM2B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ITM2B Antikörper

Sequenz: CSRTVKKNII EEN

Spezifität: The antibody recognizes the typical amyloid deposits in brains of patients suffering from the disease. This antibody has been developed against the carboxy terminal extracellular sequence of the mutated BRI protein.

Aufreinigung: Affinity chromatography.

Immunogen: Peptide coupled to carrier protein.

Anwendungsinformationen

Applikationshinweise: Suitable for Immunohistochemistry on frozen sections. Suggested positive control: pathological brain sections. (Not recommended in Western blots).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg /ml

Buffer: PBS, pH 7.2, containing 0.09 % sodium azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2-8 °C (Lyophilized) or reconstituted in small aliquots at -20 °C.

Details zu ITM2B

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Andere Bezeichnung: ITM2B

Hintergrund: The mutated BRI protein (ITM2B) was identified in patients with familial British dementia. The unusual 277 residue precursor protein releases a 34-residue amyloidogenic peptide by the action of the protease furin, leading to the deposition of a protein fragment that seems to be involved in the pathogenesis of familial British dementia.Synonyms: BRI, BRI2, ITM2B, Integral membrane protein 2B, Transmembrane protein BRI

Gen-ID: 9445

NCBI Accession: NP_068839

UniProt: Q9Y287