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Plakophilin 3 Antikörper (N-Term)

PKP3 Reaktivität: Human, Maus, Hund WB, IHC (fro), IF, IHC (p) Wirt: Maus Monoclonal 23E3-4 unconjugated
Produktnummer ABIN112378
  • Target Alle Plakophilin 3 (PKP3) Antikörper anzeigen
    Plakophilin 3 (PKP3)
    Bindungsspezifität
    • 9
    • 9
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 570-589, N-Term
    Reaktivität
    • 41
    • 10
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Hund
    Wirt
    • 25
    • 15
    • 1
    Maus
    Klonalität
    • 28
    • 13
    Monoklonal
    Konjugat
    • 24
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Plakophilin 3 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 17
    • 12
    • 11
    • 7
    • 7
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody 23E3/4 reacts with an epitope located between residues 570-589 in Human Plakophilin-3.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse and Canine (Dog).
    Aufreinigung
    Purified
    Immunogen
    Synthetic peptide corresponding to amino acid residues 570-589 of Human Plakophilin-3 coupled to Keyhole Limpet Hemocyanin via an additional cysteine residue at the N- terminus (CFTPQSRRLRELPLAADALTF).
    Klon
    23E3-4
    Isotyp
    IgG2b
    Top Product
    Discover our top product PKP3 Primärantikörper
  • Applikationshinweise
    This antibody is suitable for Immunocytochemistry (methanol-and paraformaldehyde-fixedcells), Immunohistochemistry on frozen and paraffin embedded tissues,Immunoprecipitation and Western blot detection. For optimal results, fixed cells and frozen tissues should be treated with 0.2 % Triton-X 100for, respectively, 5 min and 15 min prior to incubation with primary antibody. Recommended dilutions: Immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) asdetection reagent: 1/25-1/200. Immunoblotting: 1/100-1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS with 0.09 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    Plakophilin 3 (PKP3)
    Andere Bezeichnung
    Plakophilin 3 / PKP3 (PKP3 Produkte)
    Synonyme
    wu:fa97f09 antikoerper, wu:fk69a12 antikoerper, zgc:136656 antikoerper, PKP3 antikoerper, 2310056L12Rik antikoerper, plakophilin 3a antikoerper, plakophilin 3 antikoerper, plakophilin-3 antikoerper, plakophilin 3 L homeolog antikoerper, pkp3a antikoerper, PKP3 antikoerper, LOC450921 antikoerper, pkp3.L antikoerper, Pkp3 antikoerper
    Hintergrund
    Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells [1]. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin- 3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalisation, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin- 3 displays a dual intracellular localisation in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular mass of 87 kD.Synonyms: Plakophilin-3
    Gen-ID
    11187
    NCBI Accession
    NP_009114
    UniProt
    Q9Y446
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