Desmin Antikörper

Produktnummer ABIN112305

Der Maus Monoklonal anti-Desmin Antikörper (Klon D9) (ABIN112305) detektiert spezifisch Desmin in WB, IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Huhn, Schwein und Kaninchen.

Kurzübersicht für Desmin Antikörper (ABIN112305)

Target: Desmin (DES)

Reaktivität: Human, Ratte, Maus, Huhn, Schwein, Kaninchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Desmin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: D9

Produktdetails anti-Desmin Antikörper

Spezifität: D9 reacts exclusively with Desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma.

Kreuzreaktivität (Details): Species reactivity (tested):Chicken, Human, Mouse, Rabbit, Rat, Swine.

Aufreinigung: Purified

Immunogen: Desmin isolated from human leiomyoma.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: D9 is suitable for immunoblotting (1: 100 - 1: 1000) and immunohistochemistry on frozenand paraffin embedded tissues (recommended range is 1: 25 - 1: 200 forimmunohistochemistry with avidinbiotinylated horseradish peroxidase complex (ABC) asdetection reagent).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Desmin

Target: Desmin (DES)

Andere Bezeichnung: Desmin

Hintergrund: Desmin (53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.Synonyms: DES

Gen-ID: 1674

NCBI Accession: NP_001918

UniProt: P17661