Fibronectin Antikörper

Produktnummer ABIN112024

Dieser Maus Monoklonal Antikörper detektiert spezifisch Fibronectin in IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für Fibronectin Antikörper (ABIN112024)

Target: Fibronectin

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fibronectin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: EP5

Produktdetails anti-Fibronectin Antikörper

Spezifität: Recognizes Fibronectin specifically in connective tissues and vessels. No reactivity with the soluble dimeric form of Fibronectin (plasma Fibronectin), but highly reactive with matrix Fibronectin. Animal biodistribution experiments have shown that after intravenous administration, EP-5 antibody localizes to tumor vessels where it binds to the underlying basement membrane. At the same time the antigen recognized by EP-5 antibody is not accessible in normal tissue to circulating antibody indicating that this antibody can be used to target tumor vessels specifically in vivo.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: Protein A chromatography

Immunogen: Native human fibronectin (matrix)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on frozen and paraffin embedded sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS, pH 7.2, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C foor one month or (in aliquots) at -20 °C for longer.

Details zu Fibronectin

Target: Fibronectin

Hintergrund: Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They occur as dimers of two 250 kDa subunits. They have binding domains for bacterial proteins, collagens, heparin-like molecules and fibrin. Cellular fibronectin is widely distributed in the stroma of malignant tumours. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins).Synonyms: CIG, Cold-insoluble globulin, FN1

Gen-ID: 2335

NCBI Accession: NP_002017

UniProt: P02751