Tyrosine Hydroxylase Antikörper
Kurzübersicht für Tyrosine Hydroxylase Antikörper (ABIN1112833)
Target
Alle Tyrosine Hydroxylase (TH) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Immunogen
- Purified rat TH.
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Isotyp
- IgG1
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Applikationshinweise
- WB (1:100-400), IHC-P (1:50-200), IHC-Fr (1:100-500). Other applications have not been tested. The optimal dilutions should be determined by end user.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- TBS (0.1M), 30% Glycerol and 0.01% Sodium Azide.
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Konservierungsmittel
- Sodium azide, Thimerosal (Merthiolate)
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.
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Haltbarkeit
- 12 months
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- Tyrosine Hydroxylase (TH)
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Andere Bezeichnung
- Tyrosine Hydroxylase
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Hintergrund
- Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral symphatic neurons and the adrenal medulla. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. It also can be inhibited by the drug alpha-methyl-para-tyrosine (metirosine). This drug is rarely used and can cause depression, but it is useful in treating pheochromocytoma and also resistant hypertension.
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Pathways
- Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour
Target
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