PRSS1 Antikörper

Produktnummer ABIN7101954

Der Maus Monoklonal anti-PRSS1 Antikörper wird verwendet zum Nachweis von PRSS1 in Proben von Human. Er wurde validiert für EIA.

Kurzübersicht für PRSS1 Antikörper (ABIN7101954)

Target: PRSS1 (Protease, serine, 1 (Trypsin 1) (PRSS1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRSS1 Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA)

Klon: 401

Produktdetails anti-PRSS1 Antikörper

Spezifität: Human pancreatic trypsin. Recognizes specifically pancreatic trypsin. Does not cross react with Pancreatic Chymotrypsin.

Aufreinigung: Protein G affinity chromatography.

Immunogen: Purified human pancreatic trypsin

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: May be used in immunoassays to detect and quantitate Pancreatic Trypsin.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL (OD 280 nm)

Buffer: PBS, pH 7.4 without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.

Details zu PRSS1

Target: PRSS1 (Protease, serine, 1 (Trypsin 1) (PRSS1))

Andere Bezeichnung: Trypsin-1 / PRSS1

Hintergrund: The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3, also known as Trypsin-4, is expressed in the brain in addition to the pancreas.Synonyms: Beta-trypsin, Cationic trypsinogen, Serine protease 1, TRP1, TRY1, TRYP1, Trypsin I

Gen-ID: 5644

NCBI Accession: NP_002760

UniProt: P07477