Fibrinogen Antikörper

Produktnummer ABIN110984

Der Maus Monoklonal Anti-Fibrinogen-Antikörper wurde für WB und EIA validiert. Er ist geeignet, Fibrinogen in Proben von Human zu detektieren.

Kurzübersicht für Fibrinogen Antikörper (ABIN110984)

Target: Fibrinogen

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fibrinogen Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: FgA

Produktdetails anti-Fibrinogen Antikörper

Aufreinigung: Gel filtration and anion exchange chromatography

Immunogen: Purified human Fibrinogen

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA, RIA, westernblot (non-reducing conditions, in this application binds alpha-chain offibrinogen).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 0.5 mL sterile distilled water

Buffer: 10 mM Sodium Phosphate, 0.15 M NaCl, pH 7.4, 0.01 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2-8 °C for one month or (in small aliquots) at -20 °C for longer.

Details zu Fibrinogen

Target: Fibrinogen

Hintergrund: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/mL. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease. All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.Synonyms: FGA, FGB, FGG