IKZF4 Antikörper (N-Term)

Produktnummer ABIN1109609

Der Kaninchen Polyklonal Anti-IKZF4-Antikörper wurde für WB validiert. Er ist geeignet, IKZF4 in Proben von Human, Maus, Ratte und Hund zu detektieren.

Kurzübersicht für IKZF4 Antikörper (N-Term) (ABIN1109609)

Target: IKZF4 (IKAROS Family Zinc Finger 4 (Eos) (IKZF4))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IKZF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IKZF4 Antikörper

Bindungsspezifität: N-Term

Sequenz: NSIKVEMYSD EESSRLLGPD ERLLEKDDSV IVEDSLSEPL GYCDGSGPEP

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat, Dog

Aufreinigung: Purified using Protein A affinity column

Immunogen: The immunogen for anti-ZNFN1A4 antibody: synthetic peptide directed towards the N terminal of human ZNFN1A4

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu IKZF4

Target: IKZF4 (IKAROS Family Zinc Finger 4 (Eos) (IKZF4))

Andere Bezeichnung: ZNFN1A4 / IKZF4 / EOS

Hintergrund: IKZF4 also called ZNFN1A4 is a DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence and acts as transcriptional repressor. It interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2 and may be involved in the development of central and peripheral nervous systems. Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.Synonyms: Ikaros family zinc finger protein 4, KIAA1782, Zinc finger protein Eos

Molekulargewicht: 64 kDa (585 aa)

Gen-ID: 64375

NCBI Accession: NP_071910