YAF2 Antikörper (Middle Region)

Produktnummer ABIN1109525

Der Kaninchen Polyklonal Anti-YAF2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, YAF2 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Huhn und Xenopus laevis zu detektieren.

Kurzübersicht für YAF2 Antikörper (Middle Region) (ABIN1109525)

Target: YAF2 (YY1 Associated Factor 2 (YAF2))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Huhn, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YAF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-YAF2 Antikörper

Bindungsspezifität: Middle Region

Sequenz: KGTSTRKPRP VSQLVAQQVT QQFVPPTQSK KEKKDKVEKE KSEKETTSKK

Kreuzreaktivität (Details): Species reactivity (expected):Dog, Rat, Mouse, Bovine, Chicken, African clawed frogSpecies reactivity (tested):Human

Aufreinigung: Purified on Protein A affinity column

Immunogen: The immunogen for anti-YAF2 antibody: synthetic peptide directed towards the middle region of human YAF2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 100 μL of distilled water

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the lyophised antibody at -20 °C for up to one year. Store reconstitued antibody undiluted for one month or in aliquots at -20 °C long term.

Haltbarkeit: 12 months

Details zu YAF2

Target: YAF2 (YY1 Associated Factor 2 (YAF2))

Andere Bezeichnung: YAF2

Hintergrund: YAF2 interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. YAF2 contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two have been confirmed to date.Synonyms: YY1-associated factor 2

Gen-ID: 10138

NCBI Accession: NP_005739