TSHZ3 Antikörper (Middle Region)

Produktnummer ABIN1109362

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TSHZ3 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TSHZ3 Antikörper (Middle Region) (ABIN1109362)

Target: TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSHZ3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TSHZ3 Antikörper

Bindungsspezifität: Middle Region

Sequenz: LNVEVKKEVD KEKAVTDEKP KQKDKPGEEE EKCDISSKYH YLTENDLEES

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, RatSpecies reactivity (tested):Human

Aufreinigung: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-ZNF537 antibody: synthetic peptide directed towards the middle region of human ZNF537.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu TSHZ3

Target: TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))

Andere Bezeichnung: TSHZ3 / ZNF537

Hintergrund: TSHZ3 is a transcriptional regulator involved in developmental processes. It function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. TSHZ3 associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) and regulates the development of neurons involved in both respiratory rhythm and airflow control. It promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. TSHZ3 ot ZNF537 is involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes and in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.Synonyms: KIAA1474, TSH3, Teashirt homolog 3, Zinc finger protein 537

Gen-ID: 57616

NCBI Accession: NP_065907

Pathways: Regulation of Muscle Cell Differentiation