TSFM Antikörper (N-Term)

Produktnummer ABIN1109361

Dieser Anti-TSFM-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von TSFM in WB und IHC (p). Geeignet für Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio) und Xenopus laevis.

Kurzübersicht für TSFM Antikörper (N-Term) (ABIN1109361)

Target: TSFM (Ts Translation Elongation Factor, Mitochondrial (TSFM))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSFM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TSFM Antikörper

Bindungsspezifität: N-Term

Sequenz: KQAEIWLHKE AQKEGWSKAA KLQGRKTKEG LIGLLQEGNT TVLVEVNCET

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Dog, African clawed frog, Bovine, ZebrafishSpecies reactivity (tested):Human

Aufreinigung: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-TSFM antibody: synthetic peptide directed towards the N terminal of human TSFM.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu TSFM

Target: TSFM (Ts Translation Elongation Factor, Mitochondrial (TSFM))

Andere Bezeichnung: TSFM

Hintergrund: The TSFM gene encodes a protein that is expressed in all tissues, with the highest levels of expression in skeletal muscle, liver, and kidney. It associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3). Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexesSynonyms: EF-Ts, EF-TsMt, Elongation factor Ts mitochondrial

Gen-ID: 10102

NCBI Accession: NP_005717