TRIP10 Antikörper (Middle Region)

Produktnummer ABIN1109339

Produktdetails anti-TRIP10 Antikörper

Target: TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Zebrafisch (Danio rerio), Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIP10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FEGSSEGTIS MAEGEDLSLM EEDKGDGWTR VRRKEGGEGY VPTSYLRVTL

Kreuzreaktivität (Details): Species reactivity (expected):Rat, Mouse, Bovine, Zebrafish, African clawed frog, RabbitSpecies reactivity (tested):Human

Aufreinigung: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-TRIP10 antibody: synthetic peptide directed towards the middle region of human TRIP10.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu TRIP10

Target: TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))

Andere Bezeichnung: TRIP10 (TRIP10 Produkte)

Hintergrund: TRIP10 is required for translocation of GLUT4 to the plasma membrane in response to insulin signaling and to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. It binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules and also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. TRIP10 is further required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells and may be required for the lysosomal retention of FASLG/FASL.Synonyms: CIP4, Cdc42-interacting protein 4, Protein Felic, STOT, STP, Salt tolerant protein, TRIP-10, Thyroid receptor-interacting protein 10

Gen-ID: 9322

NCBI Accession: NP_004231