TRIM13 Antikörper (Middle Region)

Produktnummer ABIN1109332

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TRIM13 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Rind (Kuh).

Kurzübersicht für TRIM13 Antikörper (Middle Region) (ABIN1109332)

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Reaktivität: Human, Maus, Ratte, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TRIM13 Antikörper

Bindungsspezifität: Middle Region

Sequenz: DTLETSKRKS LQLLTKDSDK VKEFFEKLQH TLDQKKNEIL SDFETMKLAV

Kreuzreaktivität (Details): Species reactivity (expected):Rat, Mouse, BovineSpecies reactivity (tested):Human

Aufreinigung: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-TRIIM13 antibody: synthetic peptide directed towards the middle region of human TRIM13

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu TRIM13

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Andere Bezeichnung: TRIM13 / RNF77

Hintergrund: TRIM13 is an E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. TRIM13 enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, regulates ER stress-induced autophagy, and may act as a tumor suppressor.Synonyms: B-cell chronic lymphocytic leukemia tumor suppressor Leu5, LEU5, Leukemia-associated protein 5, Putative tumor suppressor RFP2, RFP2, RING finger protein 77, Tripartite motif-containing protein 13

Gen-ID: 10206

NCBI Accession: NP_005789