TRIB3 Antikörper (N-Term)

Produktnummer ABIN1109329

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TRIB3 in WB, IHC (fro) und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TRIB3 Antikörper (N-Term) (ABIN1109329)

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Produktdetails anti-TRIB3 Antikörper

Bindungsspezifität: N-Term

Spezifität: Reacts with Human 39 kDa TRIB-3 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from N-terminal domain of Human TRIB-3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None

Handhabung: Avoid repeated freezing and thawing.

Details zu TRIB3

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Andere Bezeichnung: TRIB3

Hintergrund: A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.Synonyms: NIPK, SKIP3, TRB-3, TRB3, Tribbles homolog 3

Gen-ID: 57761

NCBI Accession: NP_066981

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Lipid Metabolism by PPARalpha