TREM1 Antikörper

Produktnummer ABIN1109324

Produktdetails anti-TREM1 Antikörper

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TREM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Functional Studies (Func), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes human triggering receptor expressed on myeloid cells 1 (TREM-1). It recognizes both membrane bound and soluble TREM-1. Also, the antibody neutralizes the interaction between TREM-1 and its ligand.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G

Immunogen: Recombinant TREM-1 - IgG1 fusion protein

Klon: 6B1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu TREM1

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Andere Bezeichnung: TREM1 (TREM1 Produkte)

Synonyme: TREM1 antikoerper, CD354 antikoerper, TREM-1 antikoerper, triggering receptor expressed on myeloid cells 1 antikoerper, TREM1 antikoerper, Trem1 antikoerper, LOC100349504 antikoerper

Hintergrund: TREM-1 is a transmembrane glycoprotein belonging to a family related to the natural killer cell receptors. TREM-1 is an important activating receptor, of 26 kDa, involved in the innate inflammatory response and in sepsis. TREM-1 is expressed at low levels in the early development of the hematopoietic system and in the promonoistic stage and at high levels on neutrophil granulocytes (PMN), monocytes, and macrophage subsets. The expression of TREM-1 is upregulated by microbial products, that is, by toll-like receptor ligands such as lipoteichoic acid (LTA) of Gram-positive or lipopolysaccharide (LPS) of Gram-negative bacteria. Ligation of TREM-1 is synergistic with TLR agonists on the activation of receptor bearing cells. Platelets express a natural ligand for TREM-1. Receptor ligation activates the full repertoire of effector functions. TREM-1 is also produced in a soluble form (sTREM-1) of 17 kDa which is released in humans after endotoxin exposition or in patients suffering from severe pneumonia or sepsis. sTREM-1 can be measured in biological fluids and may be useful as a diagnostic tool.Synonyms: Triggering receptor expressed on monocytes 1, Triggering receptor expressed on myeloid cells 1

Gen-ID: 54210

NCBI Accession: NP_061113

UniProt: Q9NP99