SYT1 Antikörper

Produktnummer ABIN1109184

Dieses Anti-SYT1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SYT1 in WB, IF und IP. Geeignet für Ratte.

Kurzübersicht für SYT1 Antikörper (ABIN1109184)

Target: SYT1 (Synaptotagmin I (SYT1))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SYT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 1D12

Produktdetails anti-SYT1 Antikörper

Spezifität: This antibody reacts with Synaptotagmin 1 and 2 (58 kDa/60 kDa) on Western blotting. Synaptotagmin 1 has a predicted molecular weight of 47 kDa but it migrates at ~65 kDa. It is reported that this clone (1D12) recognizes rat synaptotagmin residues (99-104 aa) in the reference number 17).

Kreuzreaktivität (Details): Species reactivity (tested):Rat

Aufreinigung: Protein A agarose

Immunogen: Chicken brain synaptic membrane

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2, without preservatives

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu SYT1

Target: SYT1 (Synaptotagmin I (SYT1))

Andere Bezeichnung: Synaptotagmin-1

Hintergrund: Synaptotagmins are a family of at least 15 Ca2+-binding, membrane-trafficking proteins that act as calcium sensors regulating neurotransmitter release. Synaptotagamins are expressed in both vesicular and plasma membranes where they are involved in lipid rearrangements required during synaptic vesicle fusion. Synaptotagmins also interact with calcium channels, sodium channels, b-SNAP, neurexins, and other neural proteins in the absence of Ca2+, suggesting a role in presynaptic functions. Synaptotagmins exhibit differential expression, with synaptotagmins 1-5 expressed primarily in neural and endocrine tissues. Northern blots in murine brain tissue suggest synaptotagmin 1 is primarily expressed in rostral brain regions but has low expression in regions related to motor functions.Synonyms: SVP65, SYT, SYT2, Synaptotagmin I, Synaptotagmin II, Synaptotagmin1, Synaptotagmin2, Synonyms: SYT1, SytI, SytII, p65

Gen-ID: 6857

NCBI Accession: NP_001129277

UniProt: P21579

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport