SUCNR1 Antikörper

Produktnummer ABIN1109167

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SUCNR1 in WB, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für SUCNR1 Antikörper (ABIN1109167)

Target: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUCNR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-SUCNR1 Antikörper

Spezifität: This antibody detects endogenous levels of total SUCNR1 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide from Human SUCNR1. Epitope: Internal

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 50 % Glycerol, 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SUCNR1

Target: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Andere Bezeichnung: Succinate Receptor 1 / GPR91

Hintergrund: GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.Synonyms: G-protein coupled receptor 91, P2Y purinoceptor 1-like

Gen-ID: 56670

NCBI Accession: NP_149039