Siglec H Antikörper

Produktnummer ABIN1109009

Produktdetails anti-Siglec H Antikörper

Target: Siglec H

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Siglec H Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Kreuzreaktivität (Details): Species reactivity (tested):Mouse

Aufreinigung: Protein G

Klon: 440c

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu Siglec H

Target: Siglec H

Andere Bezeichnung: Siglec-H (Siglec H Produkte)

Synonyme: 6430529G09Rik antikoerper, Siglec-H antikoerper, sialic acid binding Ig-like lectin H antikoerper, Siglech antikoerper

Hintergrund: Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo.

UniProt: Q3Y597