Siglec H Antikörper
Kurzübersicht für Siglec H Antikörper (ABIN1109009)
Target
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Kreuzreaktivität (Details)
- Species reactivity (tested):Mouse
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Aufreinigung
- Protein G
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Isotyp
- IgG2b
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 0.1 mg/mL
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Buffer
- PBS, 0.1 % bovine serum albumin
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Lagerung
- 4 °C
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Informationen zur Lagerung
- Store at 2 - 8 °C.
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- Siglec H
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Andere Bezeichnung
- Siglec-H
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Hintergrund
- Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo.
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UniProt
- Q3Y597
Target
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