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Shiga-like Toxin (Stx) (Subunit A) Antikörper

Stx Reaktivität: E. coli WB, EIA, Func Wirt: Maus Monoclonal 1-10E-011 unconjugated
Produktnummer ABIN1109002
  • Target
    Shiga-like Toxin (Stx)
    Bindungsspezifität
    Subunit A
    Reaktivität
    E. coli
    Wirt
    • 3
    Maus
    Klonalität
    • 3
    Monoklonal
    Konjugat
    • 3
    Unkonjugiert
    Applikation
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)
    Aufreinigung
    Protein G purified
    Klon
    1-10E-011
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    PBS, 0.1 % bovine serum albumin
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 2-8 °C.
  • Target
    Shiga-like Toxin (Stx)
    Hintergrund
    Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11, and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share >99?% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60?% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. Antibodies to SLT-II can also neutralize a variant of SLT-II (designated SLT-Iiv) produced by strains of E.coli that cause edema. SLT-IIv is cytotoxic for Vero but not HeLa cells, distinguishing it from SLT-II. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.Synonyms: SLT-2 A subunit, SLT-2a, SLT-IIa, Verocytotoxin 2 subunit A, Verotoxin 2 subunit A, rRNA N-glycosidase 2, stx2A, stxA2
    Gen-ID
    10730
    UniProt
    P09385
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