SCD Antikörper

Produktnummer ABIN1108939

Dieses Maus Monoklonal-Antikörper erkennt spezifisch SCD in WB, IP, IHC (fro) und EIA. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für SCD Antikörper (ABIN1108939)

Target: SCD (Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SCD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: CD-E10

Produktdetails anti-SCD Antikörper

Spezifität: This antibody reacts to SCD / SCD1.

Aufreinigung: Affinity Purified

Immunogen: Full length recombinant protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS, pH 7.4 with 0.05 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SCD

Target: SCD (Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD))

Andere Bezeichnung: SCD / SCD1

Hintergrund: Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as insulin, leptin, carbohydrate, fatty acids and temperature. The enzyme (mouse 355aa, rat 358aa, ~37 KDa) is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. The SCD-1 expression is higher in female than male mouse. The repression of RNA levels and enzyme activity of hepatic SCD-1 by Leptin has been shown to significantly reduce the triglyceride storage, VLDL production and therefore an increase in fatty acid oxidation. Inhibition of SCD-1 could be of benefit for treatment of obesity, hepatic steatosis and other metabolic disorders.Synonyms: Acyl-CoA desaturase, Delta(9)-desaturase, Fatty acid desaturase, Stearoyl-CoA desaturase

Gen-ID: 6319

NCBI Accession: NP_005054

UniProt: O00767

Pathways: Brown Fat Cell Differentiation