S100A12 Antikörper

Produktnummer ABIN1108920

Der Maus Monoklonal anti-S100A12 Antikörper (Klon 19F5) (ABIN1108920) detektiert spezifisch S100A12 in WB, EIA und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für S100A12 Antikörper (ABIN1108920)

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser S100A12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 19F5

Produktdetails anti-S100A12 Antikörper

Spezifität: Reacts with 10 kDa Human S100A12 protein. No cross reaction with the other S100 protein family.

Aufreinigung: Affinity Chromatography on Protein A

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in distilled water.

Buffer: PBS, None

Details zu S100A12

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Andere Bezeichnung: S100A12

Hintergrund: S100 family proteins are acidic low molecular weight proteins containing 2 EF-hand calcium binding domains. They are characterised by their cell-type specific expression patterns. S100A12 is a member of the calgranulin sub-family. Calgranulins are S100 proteins that are expressed by neutrophils and also found in infiltrating monocytes and granulocytes during chronic inflammation. S100A12 is expressed in neutrophils and monocytes. It is highly abundant in resting neutrophils, comprising 5 % of total cytostolic protein. S100A12 is a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.Synonyms: CAAF1, CAGC, CGRP, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, EN-RAGE, Extracellular newly identified RAGE-binding protein, Neutrophil S100 protein, S100 calcium-binding protein A12, S100-A12

Gen-ID: 6283

Pathways: Toll-Like Receptors Cascades, S100 Proteine