PROC Antikörper (activated, Light Chain)

Produktnummer ABIN1108749

Dieses Anti-PROC-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von PROC in WB und EIA. Geeignet für Human.

Kurzübersicht für PROC Antikörper (activated, Light Chain) (ABIN1108749)

Target: PROC (Vitamin K-dependent protein C (PROC))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser PROC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: PC107

Produktdetails anti-PROC Antikörper

Bindungsspezifität: activated, Light Chain

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu PROC

Target: PROC (Vitamin K-dependent protein C (PROC))

Andere Bezeichnung: Protein C

Hintergrund: Protein C (PC) is an important regulator of the blood coagulation system. The anticoagulant PC is converted to activated protein C (APC) by the thrombomodulin (TM)-thrombin complex on the phospholipid surface of endothelial cells, monocytes, and platelets. This process is enhanced in the presence of the endothelial protein C receptor (EPCR). In addition to its regulatory function in the blood coagulation system, studies indicate important roles for APC in inflammatory processes. The administration of APC prevents lethal effects of Escherichia coli-associated sepsis in experimental animal models and appears effective for the treatment of patients with meningococcemia or acquired PC deficiency. Treatment with APC improves the clinical outcome of patients with sepsis. The anti-inflammatory activity of APC depends on its ability to suppress the secretion of cytokines as tumor necrosis factor-alpha by inflammatory cells, the activation and extravasation of leukocytes and the expression and function of adhesion molecules. APC may also suppress the expression of growth factors and members of nuclear factor-kB (NF-kB) family of transcription factors.Synonyms: APC