PMVK Antikörper (Middle Region)

Produktnummer ABIN1108679

Der Kaninchen Polyklonal Anti-PMVK-Antikörper wurde für WB, IF und IHC (p) validiert. Er ist geeignet, PMVK in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PMVK Antikörper (Middle Region) (ABIN1108679)

Target: PMVK (Phosphomevalonate Kinase (PMVK))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PMVK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PMVK Antikörper

Bindungsspezifität: Middle Region

Spezifität: This antibody detects PMVK (mid region). No cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide corresponding to a sequence mapping at the middle region of Human PMVK .Remarks: Sequence is different from the related Mouse and Rat sequence by single amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 0.2 mg Na2HPO4, 0.9 mg NaCl, 0.05 mg Thimerosal, 0.05 mg Sodium Azide, 5 mg BSA

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PMVK

Target: PMVK (Phosphomevalonate Kinase (PMVK))

Andere Bezeichnung: PMVK

Hintergrund: PMVK (phosphomevalonate kinase) is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate. It is mapped to chromosome 1p13-1q22-23 and spans more than 8.4 kb in the human genome. PMVK is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle. It was expressed highly in heart, liver, skeletal muscle, kidney and pancreas and slightly lower in brain, placenta, and lung. And PMKase gene expression is subject to regulation by sterol at the level of transcription. It is a single copy gene covering less than 15 kb in the human genome. The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence (PTS-1), Ser-Arg-Leu, at the C terminus of the protein.Synonyms: HUMPMKI, PMKI, PMKase, Phosphomevalonate kinase

Gen-ID: 10654

NCBI Accession: NP_006547

UniProt: Q15126