PLGF Antikörper (N-Term)

Produktnummer ABIN1108665

Dieses Anti-PLGF-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PLGF in WB, IHC (p) und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PLGF Antikörper (N-Term) (ABIN1108665)

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLGF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-PLGF Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects Placenta growth factor / PGF (N-term). No cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat.

Aufreinigung: Immunogen affinity purified

Immunogen: Synthetic peptide corresponding to a sequence mapping near the N-terminal of human PLGF .Remarks: Sequence is different from the related rat sequence by two different amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 1.2 % sodium acetate or neutral PBS. If 0.5 mL of PBS is used, the antibody concentration will be 100 μg/mL.

Buffer: 50 % glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu PLGF

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Andere Bezeichnung: Placenta Growth Factor / PGF

Hintergrund: Placental growth factor (PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors (VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter-and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.Synonyms: PGFL, PLGF, PlGF

Gen-ID: 5228

NCBI Accession: NP_002623

UniProt: P49763

Pathways: VEGFR1 Specific Signals