PARP4 Antikörper (AA 408-611)

Produktnummer ABIN1108587

Der Maus Monoklonal anti-PARP4 Antikörper (Klon P193-6) (ABIN1108587) detektiert spezifisch PARP4 in WB und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PARP4 Antikörper (AA 408-611) (ABIN1108587)

Target: PARP4 (Poly (ADP-Ribose) Polymerase Family, Member 4 (PARP4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PARP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: P193-6

Produktdetails anti-PARP4 Antikörper

Bindungsspezifität: AA 408-611

Spezifität: This Monoclonal antobofdy P193-6 reacts with an internal epitope (amino acids 593-599, FSKVEDY) of the minor vault protein (p193 or VPARP), which is overexpressed in various Human non-P-glycoprotein MDR tumor cell lines, accordingly to an increase in the number of vault particles.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Immunogen: E. coli lysate transformed with the pET28a(+) expression vector containing amino acids 408-611 of the p193 cDNA.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg IgG/ml

Buffer: 0.09 % Sodium Azide 9 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PARP4

Target: PARP4 (Poly (ADP-Ribose) Polymerase Family, Member 4 (PARP4))

Andere Bezeichnung: PARP4

Hintergrund: PARP-1 is a nuclear protein that is specifically cleaved by caspase-3 and caspase-6, but not by caspase-1, into a signature apoptotic fragment. PARP-2 and PARP-3 interact with PARP-1. PARP-4, also designated vault poly(ADP-ribose) polymerase (VPARP) and ADP-ribotransferase-like 1 (ADPRTL1), associates with the major vault protein (MVP) and telomerase-associated protein 1 (TEP1) to form vaults, barrel-shaped cytoplasmic ribonucleoprotein particles. PARP-4 localizes mainly to the cytoplasm but is also found in the nucleus. The PARP-4 protein is expressed widely, with highest levels observed in the kidney, and is also detected in skeletal muscle, heart, leukocytes, placenta, lung, liver, spleen, and pancreas. PARP-4 contains a PARP (ADPRT)-like catalytic domain, a C-terminal MVP-interacting domain, a domain with two sequences similar to inter-alpha-trypsin inhibitor, and an N-terminal BRCA1 C-terminus (BRCT) domain, which may be involved in protein-protein interactions.Synonyms: 193 kDa vault protein, ADPRTL1, KIAA0177, PARP-4, PARP-related/IalphaI-related H5/proline-rich, PARPL, Poly [ADP-ribose] polymerase 4, VPARP, Vault poly(ADP-ribose) polymerase

Gen-ID: 143

NCBI Accession: NP_006428

UniProt: Q9UKK3