MTDH Antikörper

Produktnummer ABIN1108306

Dieses Maus Monoklonal-Antikörper erkennt spezifisch MTDH in WB, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MTDH Antikörper (ABIN1108306)

Target: MTDH (Metadherin (MTDH))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MTDH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: 2F11C3

Produktdetails anti-MTDH Antikörper

Spezifität: This antibody reacts to Metadherin.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography on Protein G

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0,03 % sodium azide, 50 % glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu MTDH

Target: MTDH (Metadherin (MTDH))

Andere Bezeichnung: MTDH

Hintergrund: Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.Synonyms: 3D3/LYRIC, AEG-1, AEG1, Astrocyte elevated gene-1 protein, LYRIC, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein

Molekulargewicht: 64 kDa

Gen-ID: 92140

Pathways: Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization