Methylglyoxal Modified Proteins Antikörper

Produktnummer ABIN1108230

Der Maus Monoklonal anti-Methylglyoxal Modified Proteins Antikörper (Klon MGO-1) (ABIN1108230) detektiert spezifisch Methylglyoxal Modified Proteins in IHC (p), WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Diverse Spezies.

Kurzübersicht für Methylglyoxal Modified Proteins Antikörper (ABIN1108230)

Target: Methylglyoxal Modified Proteins

Reaktivität: Diverse Spezies

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: MGO-1

Produktdetails

Kreuzreaktivität (Details): Species reactivity (tested):Human. Multispecies cross reactant.

Aufreinigung: Protein G

Immunogen: MGO-modified KLH

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Antigendetails

Target: Methylglyoxal Modified Proteins

Hintergrund: Methylglyoxal (MGO) is an endogenous product of glucose metabolism. Increased production and accumulation of methylglyoxal (MGO), as well as increased modification of proteins by glycoxidation, are hallmarks of aging and diabetes. MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells. A number of studies have shown that MGO levels are significantly elevated in patients with Type 2 Diabetes and correlates well with fasting plasma glucose and hemoglobin A1c (HbA1c) levels. Moreover, increased formation of the MGO is implicated in renal dysfunction and is known to be involved in the development of DN (diabetic nephropathy).