MAMLD1 Antikörper (N-Term)

Produktnummer ABIN1108113

Dieses Anti-MAMLD1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MAMLD1 in WB. Geeignet für Human, Hund, Maus und Xenopus laevis.

Kurzübersicht für MAMLD1 Antikörper (N-Term) (ABIN1108113)

Target: MAMLD1 (Mastermind-Like Domain Containing 1 (MAMLD1))

Reaktivität: Human, Hund, Maus, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAMLD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MAMLD1 Antikörper

Bindungsspezifität: N-Term

Sequenz: LEELTKIQDP SPNELDLEKI LGTKPEEPLV LDHPQATLST TPKPSVQMSH

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, African clawed frog, DogSpecies reactivity (tested):Human

Aufreinigung: Purified using Protein A affinity column

Immunogen: The immunogen for anti-CXORF6 antibody: synthetic peptide directed towards the N terminal of human CXORF6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu MAMLD1

Target: MAMLD1 (Mastermind-Like Domain Containing 1 (MAMLD1))

Andere Bezeichnung: MAMLD1

Hintergrund: Mastermind-like domain-containing protein 1 or CXorf6 transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. MAMLD1 is expressed in fetal brain, fetal ovary, fetal testis, adult brain, ovary, skin, testis, uterus and highly expressed in skeletal muscle. Defects in MAMLD1 are a cause of X-linked hypospadias type 2 (HYSP2). Hypospadias is a common malformation in which the urethra opens on the ventral side of the penis. It is considered a complex disorder with both genetic and environmental factors involved in the pathogenesis. Hypospadias can occur alone on an apparently multifactorial basis or as part of syndromes.Mastermind-like domain-containing protein 1Synonyms: CXorf6, F18, Mastermind-like domain-containing protein 1, Protein CG1

Gen-ID: 10046

NCBI Accession: NP_005482