HTRA2 Antikörper

Produktnummer ABIN1107619

Dieses Maus Monoklonal-Antikörper erkennt spezifisch HTRA2 in WB, IP und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für HTRA2 Antikörper (ABIN1107619)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HTRA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 18-01-83

Produktdetails anti-HTRA2 Antikörper

Spezifität: This antibody reacts with HtrA2/Omi (40 kDa) on Western blotting.

Aufreinigung: Protein-A Agarose Chromatography of hybridoma supernatant.

Immunogen: Human recombinant 6His tagged HtrA2/Omi.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Referenzen für anti-HTRA2 Antikörper (ABIN1107619)

Chung, Islam, Rahman, Hong: "Neuroprotective function of Omi to α-synuclein-induced neurotoxicity." in: Neurobiology of disease, Vol. 136, pp. 104706, (2021) (PubMed).

Details zu HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Andere Bezeichnung: HTRA2 / PRSS25

Hintergrund: HtrA2, also known as Omi or Serine Protease-25, is a trimeric chaperone/heat shock protein involved in the degradation of aberrantly folded proteins during cellular stress. The ubiquitous HtrA2 protein exists as two isoforms of 38 and 40 kDa and as an alternatively spliced form called D-Omi, which is predominately expressed in the kidney, colon and thyroid. HtrA2 appears to function in the progression of arthritis, aging, and tumor progression. During apoptosis, HtrA2 is released from mitochondria into the cytoplasm where it inhibits XIAP, a caspase inhibitor. Release of HtrA2 from mitochondria appears to require Bax and Bcl-2, and the resulting overexpression of HtrA2 into the cytoplasm induces caspase-independent apoptosis.Synonyms: High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2

Gen-ID: 27429

NCBI Accession: NP_037379

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity