Fibrinogen Antikörper (citrullinated)

Produktnummer ABIN1107223

Produktdetails anti-Fibrinogen Antikörper

Target: Fibrinogen

Bindungsspezifität: citrullinated

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fibrinogen Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Purified

Klon: 3F2

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL (when dissolved at 0.5 mg/mL, the BSA concentration will be 1%)

Buffer: 10 mM Ammonium Bicarbonate buffer

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C . Add 0.05% Sodium Azide for longer storage.

Details zu Fibrinogen

Target: Fibrinogen

Abstract: Fibrinogen Produkte

Synonyme: fib2 antikoerper, MGC53620 antikoerper, fibrinogen antikoerper, sb:cb892 antikoerper, wu:fa55c12 antikoerper, wu:fb20e08 antikoerper, wu:fb59b03 antikoerper, wu:fi39d04 antikoerper, zgc:92117 antikoerper, fibrinogen alpha chain antikoerper, fibrinogen gamma chain antikoerper, fga antikoerper, FGA antikoerper, LOC698244 antikoerper, CpipJ_CPIJ010090 antikoerper, FGG antikoerper

Hintergrund: Fibrinogen is a protein produced by the liver which helps stop bleeding by helping blood clots to form. Fibrinogen gets deiminated (conversion from arginin to citrullin) by Peptidyl Arginine Deiminase (PAD) in inflamed joints in patients that develop rheumatoid arthritis.Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain citrulline. These citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert arginine into citrulline in a process called citrullination or deimination. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin can get citrullinated during cell death and tissue inflammation. Patients with rheumatoid arthritis often (at least 80 % of them) develop an immune response against proteins containing citrulline. Although the origin of this immune response is not known, detection of antibodies reactive with citrulline containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis.Synonyms: FGA, FGB, FGG