PI3 Antikörper (C-Term)

Produktnummer ABIN1107081

Dieses Anti-PI3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PI3 in WB, IHC (p) und EIA. Geeignet für Human.

Kurzübersicht für PI3 Antikörper (C-Term) (ABIN1107081)

Target: PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PI3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: TRAB2F

Produktdetails anti-PI3 Antikörper

Bindungsspezifität: C-Term

Spezifität: TRAB2F is an Elafin/SKALP specific antibody which shows strong reaction with fully processed Elafin/SKALP (C-terminal 57 aa) and a weaker reaction with human native full-length Elafin/SKALP. The antibody can be used for purification of human native full-length Elafin/SKALP.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu PI3

Target: PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))

Andere Bezeichnung: Elafin / PI3

Hintergrund: Elafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to Elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to Elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that Elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria.Synonyms: ESI, Elastase-specific inhibitor, PI-3, Peptidase inhibitor 3, Protease inhibitor WAP3, SKALP, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, WAP3, WFDC14

Gen-ID: 5266

NCBI Accession: NP_002629

UniProt: P19957