Dystroglycan Antikörper

Produktnummer ABIN1107039

Produktdetails anti-Dystroglycan Antikörper

Target: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Dystroglycan Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody is specific for a glycoepitope on brain bovine alpha-dystroglycan, which is absent on alpha-dystroglycan expressed in all other tissues.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat, rabbit, bovine

Aufreinigung: Protein G purified

Klon: 2238

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu Dystroglycan

Target: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Andere Bezeichnung: Dystroglycan (DAG1 Produkte)

Synonyme: LOC398500 antikoerper, dag1 antikoerper, MGC53537 antikoerper, 156DAG antikoerper, A3a antikoerper, AGRNR antikoerper, DAG antikoerper, MDDGC7 antikoerper, MDDGC9 antikoerper, DAG1 antikoerper, RAB7 antikoerper, dg antikoerper, a3a antikoerper, dag antikoerper, agrnr antikoerper, 156dag antikoerper, D9Wsu13e antikoerper, DG antikoerper, Dp427 antikoerper, Dp71 antikoerper, CG18250 antikoerper, CT41273 antikoerper, DmDG antikoerper, Dmel\\CG18250 antikoerper, atu antikoerper, dgn antikoerper, dys antikoerper, GB14967 antikoerper, APOJ antikoerper, CLI antikoerper, RATTRPM2B antikoerper, SGP-2 antikoerper, SGP2 antikoerper, SP-40 antikoerper, SP40 antikoerper, TRPM-2 antikoerper, TRPM2B antikoerper, Trpm2 antikoerper, Trpmb antikoerper, Ala-1 antikoerper, H9/25 antikoerper, Ly-27 antikoerper, Ly-6 antikoerper, Ly27 antikoerper, wu:fb83d06 antikoerper, wu:fi25f06 antikoerper, wu:fi37b08 antikoerper, zgc:109786 antikoerper, DystroGlycaN antikoerper, dystroglycan 1 L homeolog antikoerper, dystroglycan 1 antikoerper, dystroglycan 1 S homeolog antikoerper, Dystroglycan antikoerper, dystroglycan antikoerper, clusterin antikoerper, lymphocyte antigen 6 complex antikoerper, dgn-1 antikoerper, dag1.L antikoerper, dgn-2 antikoerper, dgn-3 antikoerper, DAG1 antikoerper, dag1.S antikoerper, Dag1 antikoerper, dag1 antikoerper, Dg antikoerper, LOC408826 antikoerper, Clu antikoerper, Ly6 antikoerper

Hintergrund: Alpha-dystroglycan (alpha-DG), also known as dystrophin-associated glycoprotein, is a laminin-binding protein of ~156 kDa (including glyco-groups). Alpha-DG is a component of the dystroglycan complex, which is involved in early development, morphogenesis and in the pathogenesis of muscular dystrophies. Alpha- and beta-DG are encoded by a single gene and are derived from a precursor polypeptide by posttranslational cleavage. Beta-DG is an integral membrane protein, whereas alpha-DG is membrane-associated through its noncovalent interaction with the extracellular domain of beta-DG. The alpha- and beta-DGs provide important physical linkages between components of basement membranes and cytoplasmic proteins that bind to the actin cytoskeleton. Alpha-DG is a heavily glycosylated, mucin-like protein anchored on the extracellular surface of the myotube, where it may provide linkage between the sarcolemma and extracellular matrix (ECM). Alpha-DG is expressed in a variety of fetal and adult tissues. Tissue-specific glycosylation modifies the laminin specificity of alpha-DG. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alpha-DG has been shown to colocalize with laminin in skeletal and cardiac muscle and a number of other cells including peripheral nerve, astrocytes, Purkinje neurons and kidney epithelium. Laminin-10/11 was shown to bind preferentially to brain alpha-DG. In Duchenne muscular dystrophy, the expression of alpha-DG is dramatically reduced leading to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. In the central nervous system, dystroglycan functions as a dual receptor for agrin and laminin-2 for instance in the Schwann cell membrane. Furthermore, defects in dystroglycan are central to the pathogenesis of structural and functional brain abnormalities seen in congenital muscular dystrophies (CMD).Synonyms: DAG1, Dystrophin-associated glycoprotein 1

Gen-ID: 281439

NCBI Accession: NP_776587

UniProt: O18738

Pathways: Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus