Corneodesmosin Antikörper

Produktnummer ABIN1106821

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Corneodesmosin in WB, EIA und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Corneodesmosin Antikörper (ABIN1106821)

Target: Corneodesmosin (CDSN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Corneodesmosin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Corneodesmosin Antikörper

Spezifität: This antibody reacts with Human 51 kDa CDSN protein. May cross react with proteins from other species.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from N-termiknal domain of Human CDSN.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Corneodesmosin

Target: Corneodesmosin (CDSN)

Andere Bezeichnung: Corneodesmosin / CDSN

Hintergrund: Defects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520], also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade. Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300], also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels.Synonyms: S protein

Gen-ID: 1041

NCBI Accession: NP_001255