CNF1 (C-Term) Antikörper

Produktnummer ABIN1106726

Der Maus Monoklonal Anti- Antikörper wurde für WB, Func, DB und EIA validiert. Er ist geeignet, in Proben von E. coli zu detektieren.

Kurzübersicht für CNF1 (C-Term) Antikörper (ABIN1106726)

Target: CNF1

Reaktivität: E. coli

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Functional Studies (Func), Dot Blot (DB), Enzyme Immunoassay (EIA)

Klon: NG8

Produktdetails

Bindungsspezifität: C-Term

Aufreinigung: Protein G purified

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 2-8 °C.

Antigendetails

Target: CNF1

Hintergrund: CNF1 and CNF2 belong to a family of bacterial toxins that target the small GTP-binding Rho proteins that regulate the actin cytoskeleton. Members of this toxin family typically inactivate Rho, however, CNF1 and the highly related CNF2 activate Rho by deamidation. CNF1 is more frequently associated with E.coli strains that cause extraintestitinal infections in humans, particularly those of the urinary tract (such as cystitis, pyelonephritis and prostatitis). In CNF1-producing uropathogenic E. coli strains, CNF1 is chromosomally encoded and typically resides on a pathogenicity island that also contains hemolysin and P fimbria- related genes. Both CNF1 and the highly related, plasmid-encoded CNF2 are monomeric, cytoplasmic toxins of approximately 115 kDa. CNF1 can be structurally organized into three functional domains the N-terminal, central and the C-terminal domain. The latter exhibits the catalytic activity of the toxin.

UniProt: Q46962