CCR3
Reaktivität: Human
FACS
Wirt: Maus
Monoclonal
5E8
APC
Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Buffer
50 tests in 1 mL volume of PBS, 0.09 % NaN3, 1 % BSA
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store at 2 - 8 °C.
Target
CCR3
(Chemokine (C-C Motif) Receptor 3 (CCR3))
Andere Bezeichnung
CD193 / CCR3
Hintergrund
Dendritic cells (DCs) are major antigen presenting cells (APCs) capable of stimulation resting T cells (TCs) in the primary immune response and are more potent APCs than peripheral blood monocytes or B cells. Several CC and CXC chemokines receptors were found to be expressed on some DCs and these molecules have been implicated to mediate in part the trafficking of DCs from blood to tissues and then to lymph nodes, where they form a close association with TCs in the process of antigen presentation. Recent studies have shown that CD191/CCR1 and CD193/CCR3 are potentially involved in antigen-presenting cell function of human DCs.Synonyms: C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CKR3, CMKBR3, Eosinophil eotaxin receptor