CCR3 Antikörper (FITC)

Produktnummer ABIN1105990

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CCR3 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CCR3 Antikörper (FITC) (ABIN1105990)

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCR3 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Klon: 444-11

Produktdetails anti-CCR3 Antikörper (FITC)

Spezifität: This antibody reacts with CD193 antigen. The antibody has also been reported to inhibit chemotactic migration of monocyte-derived DCs to RANTES (Ref.4). It suppresses the capacity of monocyte-derived DCs to stimulate allogenetic TCs proliferation and TCs derived IFN-γ secretion( Ref.4).

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein A agarose

Immunogen: Human CCR3 expressing transfectant (mouse pre-B cell lymphoma B300-19)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 50 tests in 1 mLvolume of 10 μM NaPB, 0.09 % NaN3, 1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu CCR3

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Andere Bezeichnung: CD193 / CCR3

Hintergrund: Dendritic cells (DCs) are major antigen presenting cells (APCs) capable of stimulation resting T cells (TCs) in the primary immune response and are more potent APCs than peripheral blood monocytes or B cells. Several CC and CXC chemokines receptors were found to be expressed on some DCs and these molecules have been implicated to mediate in part the trafficking of DCs from blood to tissues and then to lymph nodes, where they form a close association with TCs in the process of antigen presentation. Recent studies have shown that CD191/CCR1 and CD193/CCR3 are potentially involved in antigen-presenting cell function of human DCs.Synonyms: C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CKR3, CMKBR3, Eosinophil eotaxin receptor

Gen-ID: 1232

NCBI Accession: NP_001828

UniProt: P51677