CX3CR1
Reaktivität: Human
IF
Wirt: Maus
Polyclonal
unconjugated
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Lagerung
4 °C
Szukiewicz, Kochanowski, Mittal, Pyzlak, Szewczyk, Cendrowski: "CX3CL1 (fractalkine) and TNFα production by perfused human placental lobules under normoxic and hypoxic conditions in vitro: the importance of CX3CR1 signaling." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 63, Issue 3, pp. 179-89, (2014) (PubMed).
Fractalkine, also termed neurotactin, is a membrane-bound CX3C chemokine1. Human CX3CR1, also named V28, was first cloned from human genomic DNA libraries2. A G-protein-coupled seven-transmembrane domain receptor, it was recently identified to serve as fractalkine receptor3 ,4. Human CX3CR1 has been shown to mediate both the adhesive and migratory functions of fractalkine. Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators.