Carboxy Methyl Lysine Antikörper

Produktnummer ABIN1105660

Dieser Maus Monoklonal Antikörper detektiert spezifisch Carboxy Methyl Lysine in EIA, WB, IHC (fro), IF und IHC (p).

Kurzübersicht für Carboxy Methyl Lysine Antikörper (ABIN1105660)

Target: Carboxy Methyl Lysine (CML)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Carboxy Methyl Lysine Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: CML26

Produktdetails anti-Carboxy Methyl Lysine Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Human, Multispecies cross reactant.

Aufreinigung: Protein G Chromatography

Immunogen: Carboxy Methyl Lysine (CML)-KLH

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C.

Details zu Carboxy Methyl Lysine

Target: Carboxy Methyl Lysine (CML)

Andere Bezeichnung: Carboxy Methyl Lysine

Substanzklasse: Amino Acid

Hintergrund: CML is known to be formed from the oxidation of both carbohydrates and lipids. This makes CML a biomarker of general oxidative stress. Carboxymethyl-lysine (CML) is a well-characterized glycoxidation product that accumulates in tissues with age, and its rate of accumulation is accelerated in diabetes. Glycoxidation products are a subset of advanced glycation endproducts (AGEs) that are formed by the nonenzymatic glycation and subsequent irreversible oxidation of proteins. Oxidative stress and protein modification have been implicated in the pathogenesis of the chronic complications of diabetes, including nephropathy and atherosclerosis. The accumulation of CML in long-lived tissue such as skin collagen reflects oxidative stress over an extended period of the life-span, and has been shown to be greater in patients with diabetic complications than those without complications.Synonyms: CML, Carboxymethyl-lysine