C1QBP Antikörper (AA 74-282)

Produktnummer ABIN1105609

Dieses Maus Monoklonal-Antikörper erkennt spezifisch C1QBP in WB, IP, IF, EIA und Func. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für C1QBP Antikörper (AA 74-282) (ABIN1105609)

Target: C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C1QBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Functional Studies (Func)

Klon: 02-05-74

Produktdetails anti-C1QBP Antikörper

Bindungsspezifität: AA 74-282

Kreuzreaktivität (Details): Species reactivity (tested):Human, Rat.

Aufreinigung: Protein G Chromatography

Immunogen: Recombinant gC1qR corresponding to mature gC1qR (amino acids 74-282)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C.

Details zu C1QBP

Target: C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

Andere Bezeichnung: C1QBP

Hintergrund: The molecule is an unusually acidic, single chain protein with an apparent molecular weight of 33 kDa. It does not possess a conventional sequence motif compatible with a membrane spanning segment nor a consensus site for a GPI anchor. gC1qR migrates as a single chain under both reducing and non-reducing conditions, but it behaves as an oligomer on gel-filtration in non-dissociating conditions. Its multimer formation may be a critical process by which the gC1qR molecule increases its affinity for multivalent ligands such as C1q. gC1qR has been shown to inhibit complement activation by preventing the binding of C1q to antibodies, suggesting that the binding site for gC1qR and the binding site for immune complexes, which are present on the C1q globular 'heads', may be located at the same position. gC1qR is capable of interacting with several proteins involved in blood clotting, namely, thrombin, prothrombin, the heparinbinding form of vitronectin, the ternary complex, vitronectin-thrombin-antithrombin, as well as high-molecular-weight kininogen and Hageman factor. Besides its role in the complement pathway, gC1qR participates in enhancement of Fc-receptor and CR1-mediated phagocytosis, procoagulant activity on platelets, and chemotactic activity on mast cells, eosinophils, neutrophils, and fibroblasts. gC1qR is expressed on a wide variety of cells and can serve as a binding site for plasma and microbial proteins. Its antigenic sites may be cryptic on cells in suspension but become exposed when the cells are fixed by bifunctional cross-linkers. Probably it is also expressed on the cell membrane as a tetramer. Crosslinking or activation may thus bring about a tetrameric assembly of gC1qR followed by a conformational change within the molecule, thereby exposing epitopes which are otherwise hidden. A form of gC1qR is also found inside the cell. Intracellular gC1qR has been shown to bind the cytoplasmic tail of the α1B-adrenergic receptor and to PKCμ.Synonyms: Complement component 1 Q subcomponent-binding protein, GC1QBP, GC1q-R protein, GC1q-R protein, Glycoprotein gC1qBP, HABP1, Hyaluronan-binding protein 1, Mitochondrial matrix protein p32, SF2P32, p32, p33, p33

UniProt: Q07021

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly